Fig. 3: Neuropathological correlations. | npj Parkinson's Disease

Fig. 3: Neuropathological correlations.

From: Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson’s disease

Fig. 3

a pS129 α-synuclein (pSyn) levels in the cingulate cortex. b pS202/T205 (AT8, pTau) levels in the cingulate cortex. c Aβ levels in the cingulate cortex. Bars represent mean ± S.E.M. with individual values plotted. d pSyn and pTau levels are highly correlated across all tissues measured. Outliers with high pTau and lower pSyn are largely GBA1-DLB/AD cases. e pSyn and Aβ levels are also correlated across all tissues, but with a bimodal distribution of Aβ. Lines represent linear regression line of best-fit and shaded area is the 95% confidence interval. a, b Welch’s ANOVA test; Dunnett’s T3 multiple comparisons test. c One-way ANOVA; Tukey’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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