Fig. 4: GCase activity in genetic and idiopathic PD. | npj Parkinson's Disease

Fig. 4: GCase activity in genetic and idiopathic PD.

From: Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson’s disease

Fig. 4

a GCase activity for all cases, normalized to all control case measures, separated by region. GCase activity is subsequently normalized by region and broken down by neuropathological disease and genetics for each of the four regions: (b) cingulate, (c) frontal, (d) putamen, and (e) cerebellum. Bars represent mean ± S.E.M. with individual values plotted. f Log normalized pSyn pathology plotted against normalized GCase activity for all samples. g Log normalized pSyn pathology plotted against normalized GCase activity but normalized and broken down by brain region. Lines represent linear regression line of best-fit and shaded area is the 95% confidence interval. c Welch’s ANOVA test; Dunnett’s T3 multiple comparisons test. a, b, d, e One-way ANOVA; Tukey’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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