Fig. 5: GlcCer in genetic and idiopathic PD. | npj Parkinson's Disease

Fig. 5: GlcCer in genetic and idiopathic PD.

From: Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson’s disease

Fig. 5

a Total GlcCer measures for all cases, separated by brain region. GlcCer levels are subsequently broken down by neuropathological disease and genetics for each of the four regions: (b) cingulate, (c) frontal, (d) putamen, and (e) cerebellum. Bars represent mean ± S.E.M. with individual values plotted. f Log normalized pSyn pathology plotted against GlcCer levels for all samples. g Log normalized pSyn pathology plotted against GlcCer levels but broken down by brain region. Lines represent linear regression line of best-fit and shaded area is the 95% confidence interval. a Welch’s ANOVA test; Dunnett’s T3 multiple comparisons test. b–e: One-way ANOVA; Tukey’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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