Fig. 7: Overall relationships between neuropathology, GCase activity, and lipid levels.

Pearson’s correlations between each of the different measure factors, including age, post-mortem interval (PMI), pathology, GCase activity and lipids are plotted here separately for cingulate (a), frontal (b), putamen (c), and cerebellum (d). Several of the protein pathologies correlate with each other; several lipid levels also correlate with each other. Of note (highlighted in orange boxes) is the positive correlation between GlcSph and protein pathologies, especially in the cingulate and frontal cortices, and to a lesser extent in the putamen. GCase activity also negatively correlated with GlcSph levels, although this was only significant in putamen and cerebellum. Plots display Pearson’s correlations with Holm’s correction for multiple comparisons. Correlations are noted also by number and those comparisons with p > 0.05 have an “X” over the intersecting box.