Fig. 3: Significant gray matter changes associated with nigral zSBRs in patients with DLB and MCI-LB.
From: Substantia nigral dopamine transporter uptake in dementia with Lewy bodies
The results are based on a general linear model for modulated voxel-wise gray matter using zSBR of anterior putamne (A), posterior putamen (B), anterior caudate (C), posterior caudate (D), and substantia nigra (E) as a predictor and age, sex, education, and intracranial volume as covariates. The intracranial volume is defined as the sum of gray matter, white matter, and cerebrospinal fluid volumes in the native space. The color scale indicates the effect sizes (r-scores) in statistical analysis. The areas bounded by the white line indicate brain regions that show significant correlations after correcting for multiple comparisons using random field theory cluster correction (corrected p < 0.05, family-wise error rate). AC anterior caudate, AP anterior putamen, DLB dementia with Lewy bodies, MCI-LB mild cognitive impairment with Lewy body, PC posterior caudate, PP posterior putamen, SN substantia nigra, zSBR age-adjusted z-score of specific binding ratio.
