Table 3 Univariate analysis for the effects of nigrostriatal FP-CIT zSBRs on the UPDRS motor score, CDR-SOB, and K-MMSE in the overall patient group.

From: Substantia nigral dopamine transporter uptake in dementia with Lewy bodies

 

UPDRS-III

CDR-SOB

 

K-MMSE

 
 

βa (SE)

P

βa (SE)

P

βa (SE)

P

AP-zSBR

−0.25 (0.64)

0.042

−0.31 (0.22)

0.015

0.24 (0.31)

0.047

PP-zSBR

−0.35 (0.54)

0.003

−0.22 (0.20)

0.071

0.12 (0.27)

0.311

AC-zSBR

−0.28 (0.67)

0.030

−0.35 (0.24)

0.009

0.25 (0.33)

0.051

PC-zSBR

−0.34 (0.90)

0.006

−0.15 (0.33)

0.253

0.08 (0.46)

0.499

SN-zSBR

−0.30 (0.75)

0.009

−0.46 (0.25)

<0.001

0.33 (0.36)

0.003

  1. AC anterior caudate, AP anterior putamen, CDR-SOB Clinical Dementia Rating-sum of boxes, DLB dementia with Lewy bodies, K-MMSE Korean version of Mini-Mental State Examination, MCI-LB mild cognitive impairment with Lewy body, PC, posterior caudate, PP posterior putamen, SN substantia nigra, UPDRS-III Unified Parkinson’s Disease Rating Scale Part III, zSBR age-adjusted z-score of specific binding ratio.
  2. aStandardized regression coefficient
  3. Data are results of general linear models for UPDRS-III, CDR-SOB, and K-MMSE scores using nigrostriatal zSBRs as predictors in patients with DLB and MCI-LB. Covariates included age, sex, and education. P values in bold is significant after multiple comparisons corrections across five predictors using the false discovery rate (FDR) method.
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