Table 3 A summary of the pathology detection patterns of aSyn non-modified and PTM antibodies on LBD substantia nigra.
Antibody | Neuronal | Glial | Extrasomal | ||||
|---|---|---|---|---|---|---|---|
LBs | Diffuse cytoplasmic with an aggregate | Punctate cytoplasmic | LNs & neuropil dots | Astroglial | Coiled body-like oligodendroglial | ||
LASH-EGTNter 1–20 | ++ | ++ | – | ++ | – | + | + |
LASH-BL 34–45 | +++ | + | +++ | +++ | +++ | + | + |
LASH-BL 80–96 | ++ | + | ++ | ++ | ++ | + | + |
BD SYN-1 91–99 | ++ | + | ++ | ++ | ++ | + | + |
2F10-E12 110–115 | +++ | ++ | – | +++ | – | ++ | + |
AB 134–138 | ++ | ++ | – | ++ | – | – | + |
LASH-BL pY39 | + | – | –/+ | + | + | + | + |
LASH pS87 | + | + | –/+ | + | – | – | + |
AB pY125 | – | + | –/+ | – | – | – | – |
AB EP1536Y pS129 | +++ | ++ | – | +++ | – | + | + |
AB pY133 | + | + | – | + | – | – | + |
AB pY136 | ++ | – | – | ++ | – | – | + |
LASH-EGT nY39 | + | + | ++ | + | ++ | – | ++ |
6A3-E9 aSyn-120 | – | + | – | – | – | – | ++ |
