Fig. 1: sNfL increases with the presence of clinical milestones.

Comparison of log(NfL) values for patients with no milestone or at least one clinical milestone (a) and of log(NfL) values stratified by the number of clinical milestones (b). Data are depicted as boxplots (center line—median, box limits—upper and lower quartiles, whiskers—1.5× interquartile range, diamonds—outliers) overlaid with individual markers for each patient (dots). Only significant differences between groups are depicted in the figure. Groups were compared using Mann–Whitney U Test (a) or a posthoc Dunn-Test after a significant Kruskal–Wallis test (p < 0.001) adjusted for false discovery rate using the Benjamini–Hochberg method (b).