Fig. 3: Relationship between tau and white matter microstructure in DLBs.
From: Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies
Statistically significant associations of cortical [18 F]-Flortaucipir with regional DTI and NODDI parameters are depicted on 3D glass brain renderings and in volumetric MNI152 space (radiological orientation) after correction for multiple comparisons with FDR. Linear regression models were adjusted for age, APOE genotype, and [11 C]-PiB, and corrected for multiple comparisons with FDR. FDR q-values are expressed as -log(q) (i.e., 1.3 -\> q = 0.05). Abbreviations: DLBs Dementia with Lewy bodies spectrum; DTI Diffusion tensor imaging, APOE Apolipoprotein E, FDR False Discovery Rate, FA Fractional anisotropy, MD Mean diffusivity, NODDI Neurite Orientation Dispersion and Density Imaging, tNDI tissue-weighted Neurite Density Index, ODI Orientation Dispersion Index; MNI152 Montreal Neurological Institute, SUVr Standardized uptake value ratio, PiB Pittsburgh Compound B.
