Fig. 5: Relationship between tau and white matter microstructure in CU.
From: Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies
Statistically significant associations of cortical [11 C]-PiB SUVr with regional DTI and NODDI parameters are depicted on 3D glass brain renderings and in volumetric MNI152 space (radiological orientation) for the CU controls. Linear regression models were adjusted for age, APOE genotype and [18 F]-Flortaucipir, and corrected for multiple comparisons with FDR. FDR q values are expressed as -log10(q) (i.e., 1.3 -> q = 0.05). Abbreviations: CU Cognitively unimpaired, DTI Diffusion tensor imaging, APOE Apolipoprotein E, FDR False Discovery Rate, FA Fractional anisotropy, MD Mean diffusivity, NODDI Neurite Orientation Dispersion and Density Imaging, tNDI tissue-weighted Neurite Density Index, ODI Orientation Dispersion Index, MNI152 Montreal Neurological Institute, SUVr Standardized uptake value ratios.
