Fig. 7: Relationships among age, APOE, cortical amyloid-β, tau PET biomarkers, and white matter microstructural injury in DLBs were examined with SEMs.
From: Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies
All direct and indirect effects visualized in this figure are statistically significant (p < 0.05). Age and APOE genotype were included as modifiers of all variables in DLBs. Arrows that join nodes indicate direct effects, while arrows that join nodes after passing through intervening mediator variables indicate indirect effects. Total effects are the sum of direct and indirect effects. The color-coding of both direct and indirect effects reflects the predictors. The effects are summarized using regression coefficients and associated standard errors. APOE Apolipoprotein E, DLBs Dementia with Lewy bodies spectrum, DTI Diffusion tensor imaging; NODDI Neurite Orientation Dispersion and Density Imaging, PiB Pittsburgh compound B, SUVr Standardized uptake value ratios, SEM Structural equation model, F Fractional anisotropy, MD Mean Diffusivity, tNDI tissue-weighted Neurite Density Index.
