Fig. 2: Genetic variants enriched in the PEG study patient cohort prioritized by pesticide exposure and disease progression.

All enriched genetic exonic variants are shown and arranged by measures of exposure to the cotton cluster pesticides and disease progression. For pesticide exposure, scores represent scaled values derived from weighting individual pesticides in the cotton cluster by toxicity and exposure occurrence where a score of 1 represents the reference level for the cohort while higher numbers indicate increased toxicity and/or exposure. For disease progression, scores are scaled such that a score of 1 represents baseline symptom severity and rate of progression in the cohort while higher numbers represent faster progression and/or more severe symptoms. Variants with both an average weighted sum of 1 or greater for cotton cluster pesticide exposure and an average disease progression score of 1 or greater are highlighted. Blue points were found to be enriched in subjects of European/non-Hispanic descent while red points represent variants found to be enriched in patients of Hispanic descent. For LAMP1, the same variant is shown in both blue and red as it is enriched in both sub-populations. Genes with multiple variants identified and/or genes with single variants identified in multiple individuals in the patient cohort are highlighted. Arrows indicate single variants while circles represent two variants.