Table 1 Cohort demographics and clinical characteristics at baseline examination
From: Lysosomal genes contribute to Parkinson’s disease near agriculture with high intensity pesticide use
N (%) or Mean ± SD | All Patients (N = 757) | Disease Progression: All Patients (N = 386) | Progression: European Ancestry (N = 320) | Progression: Hispanic Ancestry (N = 66) |
|---|---|---|---|---|
Age at diagnosis, years | 67.7 ± 10.6 | 66.2 ± 10.0 | 67.0 ± 9.6 | 62.4 ± 10.9 |
Sex, Male | 468 (61.8%) | 241 (62.4%) | 192 (60.0%) | 49 (74.2%) |
Ethnicity, Hispanic | 138 (18.2%) | 66 (17.1%) | 0 (0%) | 66 (100%) |
Race, White | 695 (91.8%) | 360 (93.3%) | 320 (100%) | 40 (60.6%) |
PD duration at diagnosis, years | 2.9 ± 2.5 | 2.8 ± 2.4 | 2.6 ± 2.4 | 3.5 ± 2.6 |
Levodopa Use (yes) | 530 (70.0%) | 269 (69.7%) | 226 (70.6%) | 43 (65.2%) |
LED, mg/day | 311 ± 289 | 290 ± 277 | 296 ± 284 | 269 ± 239 |
UPDRS-III | 21.5 ± 11.4 | 20.1 ± 10.6 | 18.9 ± 9.9 | 25.8 ± 12.1 |
Rigidity | 3.5 ± 2.5 | 3.4 ± 2.5 | 3.2 ± 2.3 | 4.3 ± 3.0 |
Bradykinesia | 1.1 ± 0.9 | 1.0 ± 0.8 | 0.9 ± 0.8 | 1.5 ± 0.9 |
Tremor | 3.1 ± 2.6 | 3.1 ± 2.5 | 3.0 ± 2.4 | 3.3 ± 2.7 |
PIGD | 1.7 ± 1.6 | 1.4 ± 1.3 | 1.3 ± 1.3 | 1.8 ± 1.5 |
HY (mean) | 2.1 ± 0.8 | 2.0 ± 0.7 | 1.9 ± 0.7 | 2.2 ± 0.7 |
