Fig. 5: Evaluation of the consistency of streamlined SAA utilizing skin homogenate from PD patients and HC.
From: A skin-specific α-Synuclein seeding amplification assay for diagnosing Parkinson’s disease
a–d In the streamlined SAA reactions, skin homogenates from both PD patients and HC were subjected to analysis. The seeding activity of αSynD was detected in all 20/20 skin samples from PD patients at DTS-lab and 19/20 of the same PD patients at YX-lab (a and b). Conversely, none of the samples from HC induced seeding activity at YX-lab, while 1/12 skin samples from HC exhibited seeding activity at DTS-lab (c and d). The curves depicted in the graphs were generated by plotting the average fluorescence intensities of each sample over time.
