Table 2 Comparison of streamlined αSyn SAA results between DTS-lab and YX-lab
From: A skin-specific α-Synuclein seeding amplification assay for diagnosing Parkinson’s disease
PD | HC | |||
|---|---|---|---|---|
YX-lab | DTS-lab | YX-lab | DTS-lab | |
Samples analyzed | 20 | 20 | 12 | 12 |
αSyn’s seeding activity | 19 | 20 | 0 | 1 |
Meantime at fluorescence threshold (SD) | 7.6 (1.1) | 6.8 (1.3) | NA | NA |
Seeding activity vs. clinical diagnosis (sensitivity) | 95.0% | 100% | 0 | 8.3% |
Disease-specific interrater agreement between labs | 95.0% | 91.7% | ||
Overall interrater agreement between labs | 93.8% (Kappa = 0.87, 95% Cl 0.69–1.00) | |||
