Table 2 Demographic and clinical characteristics of the PD clusters not adjusted for global atrophy
From: MRI subtypes in Parkinson’s disease across diverse populations and clustering approaches
Control group (N = 233) | Cl1 (N = 302) | Cl2 (N = 148) | Cl3 (N = 183) | Statistics (H, p value) | Post-hoc | |
|---|---|---|---|---|---|---|
Age, years (median, IQR) | 64.5 (13.3) | 64.40 (14.75) | 61.08 (16.11) | 67.74 (11.52) | H = 40.586 p < 0.001 | cl1 vs cl2 cl1 vs cl3 cl2 vs cl3 |
Sex (men/women) | 148/85 64% men | 190/112 63% men | 88/60 59% men | 123/60 67% men | χ2 = 2.166 p = 0.339 | |
Disease duration, years (median, IQR) | NA | 1 (3.65) | 1 (2.73) | 1.38 (4.63) | H = 2.281 p = 0.320 | |
Education, years (median, IQR) | 16 (5) | 15 (5) | 16 (5) | 15 (5) | H = 2.749 p = 0.253 | |
Hoehn & Yahr scale (1/1.5/2/2.5/3/4) | NA | 85/2/174/5/22/6 | 57/2/73/2/7/2 | 48/1/102/5/19/2 | χ2 = 12.013 p = 0.284 | |
Medicated (yes/no) % Medicated | NA | 117/184 39% | 60/88 40% | 81/102 44% | χ2 = 1.376 p = 0.503 | |
UPDRS part III (median, IQR) | NA | 20 (15) | 18 (13) | 22 (13) | H = 6.309 p = 0.043 | cl2 vs cl3 |
MoCA (median, IQR) | 28 (2) | 27 (3) | 28 (3) | 27 (3) | H = 2.551 p = 0.279 | |
MCI (yes/no) % MCI | 14/170 8% | 47/184 20% | 13/96 12% | 38/99 28% | χ2 = 9.307 p = 0.010 | cl2 vs cl3 |
Depression (presence/absence) % Presence | NA | 47/185 20% | 26/85 23% | 32/110 23% | χ2 = 0.536 p = 0.765 | |
RBD (presence/ absence) % Presence | NA | 55/99 36% | 27/44 38% | 37/52 42% | χ2 = 0.823 p = 0.663 | |
WM-hypo/eTIV (median, IQR) | 0.0007 (0.0006) | 0.0010 (0.0010) | 0.0008 (0.0006) | 0.0015 (0.0014) | H = 69.533 p < 0.001 | cl1 vs cl2 cl1 vs cl3 cl2 vs cl3 |
Cohort (Barcelona UB-Clínic/EXPANd/KIMOVE/PPMI) | 44/38/0/151 | 46/40/61/155 | 26/15/36/71 | 35/20/39/89 | χ2 = 3.148 p = 0.790 |
