Fig. 5: WGCNA on LRRK2 interactors in the sPD, LRRK2-PD and control conditions. | npj Parkinson's Disease

Fig. 5: WGCNA on LRRK2 interactors in the sPD, LRRK2-PD and control conditions.

From: Transcriptomics and weighted protein network analyses of the LRRK2 protein interactome reveal distinct molecular signatures for sporadic and LRRK2 Parkinson’s Disease

Fig. 5

A The dendrogram shows the 3 co-expression modules identified among LRRK2 interactors across the 3 cohorts. Modules are represented by colours (MBlue, MBrown and MTurquoise). B–D The bubble plots show the semantic groups of GO-BPs enriched for MBlue, MBrown and MTurquoise. The bubble colour represents the adjusted-p value of the most significant GO-BP within each semantic group (reported on the vertical axis), while the bubble size represents the number of GO-BPs in each semantic group. E The heatmap shows the Module-Trait correlation between the eigengene of the 3 co-expression modules (MEblue, MEbrown and MEturquoise) and PD type. The numbers in cells and cell colours represent Pearson’s coefficients. Significant correlation was defined as Pearson’s p-value < 0.05 (marked with *).

Back to article page