Fig. 6: The LRRK2net. | npj Parkinson's Disease

Fig. 6: The LRRK2net.

From: Transcriptomics and weighted protein network analyses of the LRRK2 protein interactome reveal distinct molecular signatures for sporadic and LRRK2 Parkinson’s Disease

Fig. 6

A The network graph shows the LRRK2net, in which nodes represent the LRRK2 interactors (N = 338), while edges represent the “2-layer” PPIs (N = 1345). Node size refers to the node degree. Interactors with higher centrality (with degree ≥ 24) were colour-coded according to their degree. B The bar graph shows the distribution of degrees for the LRRK2 interactors. C The log–log plot shows that the LRRK2net follows the power law, in which the X-axis represents the log-transformed degree (logD), while the Y-axis represents the log-transformed frequency of a LRRK2 interactor with a certain degree level (log(n(D))). The scatters fit a linear regression line with R-square = 0.8606.

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