Table 4 Differences of clinical characteristics between PD patients with and without AS accumulation in the GI tract

From: Diagnostic accuracy and predictors of alpha-synuclein accumulation in the gastrointestinal tract of Parkinson’s disease

Characteristic

Patients with PD

p-value

AS+ (N = 73)

AS− (N = 24)

Sex, no. (%)

Male

45 (61.6)

12 (50.0)

0.315

Female

28 (38.4)

12 (50.0)

 

Age, mean (SD), yr

At surgery

71.4 (6.7)

69.7 (7.4)

0.308

At the final follow-up visit

75.9 (6.5)

75.4 (8.5)

0.750

At symptom onset

66.4 (7.5)

68.0 (8.8)

0.410

At diagnosis

68.5 (7.9)

69.0 (8.5)

0.790

Duration, mean (SD), yr

Onset to surgery

4.9 (4.9)

1.8 (4.1)

0.005

Onset to diagnosis

2.0 (2.6)

1.0 (1.0)

0.006

Onset to the final follow-up visit

9.5 (4.5)

7.4 (5.1)

0.063

Surgery to the final follow-up visit

4.5 (3.4)

5.7 (3.9)

0.178

Frequency of patients who underwent surgery before the symptom onset, No. (%)

8 (11.0)

4 (16.7)

0.484

HY stage at the year of surgery (available in 29 patients), No. (%)

1

3 (4.1)

1 (4.2)

0.998

2

5 (6.8)

2 (8.3)

 

2.5

7 (9.6)

2 (8.3)

 

3

7 (9.6)

2 (8.3)

 

Surgical site, No. (%)

UGI (stomach + esophagus)

46 (63.0)

9 (37.5)

0.029

LGI (colon + rectum)

27 (37.0)

15 (62.5)

 
  1. PD Parkinson’s disease, AS alpha-synuclein, HY Hoehn and Yahr, GI gastrointestinal, UGI upper GI, LGI tract lower GI tract.