Table 2 A general linear model analysis of serum metabolites in the PD group

Objective Variable	Explanatory variable	Unstandardized Coefficient		Standardized Coefficient	t	P	Adjusted R²	Model p-value
Objective Variable	Explanatory variable	B	SE	Beta	t	P	Adjusted R²	Model p-value
Hypoxanthine	Constant	3.10	5.91		0.52	0.6021
	Inosine	0.51	0.09	0.68	5.96	<0.0001
	Group (1 = PD; 0=Ctrl)	−1.73	1.35	−0.15	−1.28	0.2049
	Inosine x Group	−0.22	0.15	−0.18	−1.43	0.1567
	Age	−0.03	0.07	−0.04	−0.41	0.6803
	Sex (1=Male, 0=Female)	0.05	1.60	0.00	0.03	0.9758
	Weight	0.10	0.13	0.22	0.78	0.4357
	BMI	−0.18	0.36	−0.13	−0.50	0.6216
							0.38	<0.0001
Xanthine	Constant	−5.54	3.74		−1.48	0.1427
	Hypoxanthine	0.19	0.08	0.35	2.35	0.0216
	Group (1 = PD; 0=Ctrl)	−0.47	0.90	−0.07	−0.52	0.6037
	Hypoxanthine x Group	−0.13	0.12	−0.17	−1.09	0.2810
	Age	0.06	0.04	0.16	1.40	0.1658
	Sex (1=Male, 0=Female)	2.14	0.97	0.34	2.20	0.0314
	Weight	−0.18	0.08	−0.71	−2.29	0.0254
	BMI	0.58	0.22	0.79	2.69	0.0089
							0.19	0.0033
Uric Acid	Constant	316.07	96.52		3.27	0.0017
	Xanthine	3.30	3.20	0.10	1.03	0.3064
	Group (1 = PD; 0=Ctrl)	−107.62	28.93	−0.52	−3.72	0.0004
	Xanthine x Group	−1.09	11.66	−0.01	−0.09	0.9255
	Age	−1.10	1.15	−0.09	−0.96	0.3416
	Sex (1=Male, 0=Female)	14.04	27.36	0.07	0.51	0.6096
	Weight	6.06	2.27	0.71	2.67	0.0095
	BMI	−10.18	6.15	−0.42	−1.66	0.1025
							0.47	<0.0001

PD Parkinson’s disease, Ctrl control, B unstandardized regression coefficient, SE standard error, Beta standardized regression coefficient, t t-statistics, P p-value. Bold values indicate statistical significance.

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