Table 1 Demographic and clinical characteristics based on OH subtypes

From: Orthostatic Hypotension: a clinical marker for the body-first subtype of patients with Parkinson’s Disease

 

Total (n = 928)

SOH (n = 224)

LOH (n = 321)

NOH (n = 383)

P

Female (%)

413 (44.5)

99 (44.2)

148 (46.1)

166 (43.3)

0.759

Age, years (mean ± SD)

62.4 ± 8.9

64.1 ± 7.7a

63.7 ± 8 .2a

60.2 ± 9.7

<0.001

Disease duration, years (mean ± SD)

7.9 ± 5.4

8.3 ± 5.2a

8.8 ± 5.5a

7.0 ± 5.3

<0.001

LED, mg (mean ± SD)

258.9 ± 80.0

267.2 ± 84.9a

269.1 ± 75.4a

245.8 ± 79.2

<0.001

Asymmetric onset (%)

480 (51.7)

117 (52.2)

164 (51.1)

199 (52.0)

0.588

Motor subtypes

 TD (%)

279 (30.1)

64 (28.6)

91 (28.3)

124 (32.4)

0.171

 Indeterminate (%)

83 (8.9)

14 (6.3)

35 (10.9)

34 (8.9)

 

 PIGD (%)

507 (54.6)

134 (59.8)

179 (55.8)

194 (50.7)

 

H&Y

 1–2.5 (%)

531 (57.2)

120 (53.6)

170 (53.0)

241 (62.9)

0.045

 3 (%)

257 (27.7)

69 (30.8)a

93 (29.0)

95 (24.8)

 

 4–5 (%)

139 (15.0)

34 (15.2)

58 (18.1)

47 (12.3)

 

 Motor fluctuations (%)

533 (57.4)

135 (60.3)

207 (64.5)a

191 (49.9)

0.002

 Dyskinesias (%)

231 (24.9)

59 (26.3)

96 (29.9)a

76 (19.8)

0.029

 FOG (%)

443 (47.7)

120 (53.6)

170 (53.0)a

153 (39.9)

0.001

 MDS-UPDRS-II (mean ± SD)

18.7 ± 8.7

20.3 ± 8.7a

20.0 ± 8.5a

16.7 ± 8.5

<0.001

 MDS-UPDRS-III (mean ± SD)

54.2 ± 19.0

57.1 ± 18.6a

57.1 ± 17.7a

50.1 ± 19.6

<0.001

 Cognitive impairment-MMSE (%)

383 (42.3)

102 (45.5)

139 (43.3)

142 (37.1)

0.165

 Cognitive impairment-MoCA (%)

652 (70.3)

170 (75.9)

237 (73.8)

245 (64.0)

0.022

 PDSS (mean ± SD)

108.7 ± 25.6

106.5 ± 25.2

107.9 ± 24.2

110.6 ± 26.9

0.159

 EDS (%)

163 (17.6)

51 (22.8)

50 (15.6)

62 (16.2)

0.097

 pRBD (%)

466 (50.2)

151 (67.4)a, b

176 (54.8)a

139 (36.3)

<0.001

 NMSS- cardiovascular (mean ± SD)

1.0 ± 2.2

1.3 ± 3.0a

1.0 ± 1.9

0.7 ± 1.8

0.008

 NMSS- digestive (mean ± SD)

6.1 ± 5.8

7.3 ± 6.2a

6.9 ± 5.9a

4.7 ± 5.2

<0.001

 Constipation (%)

614 (66.2)

171 (76.3)a

237 (73.8)a

206 (53.8)

<0.001

 Hyposmia (%)

380 (40.9)

96 (42.9)

127 (39.6)

157 (41.0)

0.685

 Anxiety (%)

536 (57.8)

140 (62.5)

183 (57.0)

213 (55.6)

0.315

 Depression (%)

553 (59.6)

149 (66.5)

192 (59.8)

212 (55.4)

0.056

 Hallucination (%)

109 (11.7)

36 (16.1)a

41 (12.8)

32 (8.4)

0.022

 SH (%)

217 (23.4)

44 (19.6)b

98 (30.5)

75 (19.6)

0.001

  1. Values are mean ± SD or number (percentage).
  2. Bold words: significant values.
  3. OH orthostatic hypotension, SOH spontaneous OH, LOH levodopa-induced OH, NOH non-OH, LED Levodopa equivalent dose in the Levodopa Challenge Test, TD tremor dominate, PIGD postural instability/gait disorder, FOG freezing of gait, MDS-UPDRS Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale, MMSE Mini-mental State Examination, MoCA Montreal cognitive assessment, PDSS Parkinson disease sleep scale, EDS excessive daytime sleepiness, pRBD probable rapid eye movement sleep behavior disorder, NMSS non-motor symptoms scale, SH supine hypertension.
  4. aP < 0.05, vs NOH.
  5. bP < 0.05, vs LOH.
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