Table 3 Comparisons of motor symptoms and quality of life between the clinical subtypes based on OH status

From: Orthostatic Hypotension: a clinical marker for the body-first subtype of patients with Parkinson’s Disease

 

SOH (n = 224)

LOH (n = 321)

NOH (n = 383)

P

MDS-UPDRS (mean±SD)

 Total scores

101.5 ± 27.7a

100.6 ± 26.7a

88.7 ± 31.0

<0.001#

 Part I

14.2 ± 6.2a

13.7 ± 6.0a

11.4 ± 5.8

<0.001#

 Part II

20.3 ± 8.7a

20.0 ± 8.5a

16.7 ± 8.5

<0.001#

 Part III

57.1 ± 18.6a

57.1 ± 17.7a

50.1 ± 19.6

<0.001#

 Part IV

6.7 ± 3.9

7.0 ± 4.1a

5.7 ± 4.2

0.002#

PDQ-39 (mean±SD)

 Total scores

51.3 ± 20.7a

47.6 ± 20.8a

41.0 ± 22.6

<0.001#

 Mobility

17.1 ± 9.9a

15.8 ± 9.9a

12.3 ± 10.1

<0.001#

 Activities of daily living

9.9 ± 5.6a

9.2 ± 5.8a

7.5 ± 6.0

<0.001#

 Emotion

7.1 ± 4.5a, b

6.1 ± 4.6a

5.0 ± 4.5

<0.001#

 Stigma

5.4 ± 4.0a

5.1 ± 4.0

4.5 ± 4.2

0.004#

 Social support

1.3 ± 1.5

1.2 ± 1.3

1.1 ± 1.6

0.054

 Cognition

4.2 ± 2.7a, b

3.5 ± 2.6a

2.8 ± 2.5

<0.001#

 Communication

2.1 ± 2.1a

1.7 ± 1.7

1.6 ± 1.9

<0.001#

 Bodily discomfort

3.0 ± 2.4a

2.7 ± 2.2

2.5 ± 2.3

0.018

  1. Bold words: significant values.
  2. OH orthostatic hypotension, SOH spontaneous OH, LOH levodopa induced OH, NOH non-OH, MDS-UPDRS Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale, PDQ-39 Parkinson’s disease questionnaire 39 item version.
  3. aP < 0.05, vs. NOH.
  4. bP < 0.05, vs. LOH.
  5. #P < 0.05, adjusted for age and duration (Multiple Linear Regression).