Table 1 presents information on how specific genes (SNCA, PRKN, PINK1, LRRK2, PARK7) are influenced by miRNAs, detailing how these miRNAs regulate their expression, the mechanisms involved, and the experimental proof supporting their involvement in PD pathogenesis

SNCA

miR-7^{117,129,130,131}

Downregulation

Inhibits translation

Patients with PD have reduced expression in SNpc of Over-expression of miR-7 reduces SNCA mRNA and protein levels

miR-153^{129,130,131,132}

Upregulation

Degrades mRNA

Over-expression of miR-153 reduces SNCA mRNA and protein levels

miR-203a-3p¹³³

Downregulation

Treatment with MMP+ resulted in decreased cell proliferation and triggered apoptosis in the SH-SY5Y cells.

Downregulation in MMP + -treated SH-SY5Y cells Leading to expression of SNCA, p53, and cleaved Caspase-3 proteins

PRKN

miR-103a-3p¹³⁴

Upregulation

Binds to 3′-UTR of Parkin mRNA

Over-expression decreases Parkin protein expression

miR-146a¹³⁵

Upregulation

Downregulates Parkin

Upregulation leads to Parkin downregulation

miR-181a¹³⁶

Upregulation

Downregulates Parkin

Over-expression decreases Parkin mRNA and protein levels

miR-218¹³⁷

Downregulation

Downregulates Parkin

Over-expression decreases Parkin’s expression

PINK1

miR-27a/b^138,139,140

Upregulation

Downregulates PINK1

Inhibits PINK1 expression by binding to 3′ UTR

LRRK2

miR-205^131,141

Downregulation

Downregulates LRRK2

Reduced expression in PD patients

Over-expression decreases LRRK2

miR-599¹⁴²

Downregulation

Downregulates LRRK2

Reduced expression in PD models; Over-expression decreases LRRK2

PARK7

miR-494^143,144

Upregulation

Downregulates DJ-1

Binds to 3′ UTR, decreases DJ-1 expression

miR-4639-5p¹⁴⁵

Upregulation

Downregulates DJ-1

Negatively regulates DJ-1 post-transcriptionally