Table 2 Summary of miRNAs that are dysregulated in PD and their downstream targets
Study | miRNAs | Dysregulation | Downstream targets | Effect of miRNA regulation on microglia (MG) |
|---|---|---|---|---|
Yao et al.84. | miR-124 | Downregulated | p62, p38, p-p65, MEKK3 | Reduces inflammation in MG in PD with p62 and p38. In SH-SY5Y human neuroblastoma cells activated with MG, p62 knockdown prevents cell apoptosis and death |
Ren et al.24. | miR-195 | Downregulated | ROCK1 | RCK1 is responsible for MG activation, by negatively regulating it |
Li et al.85. | miR-let-7a | Downregulated | STAT3 | Inhibit BV-2 MG activation and reduce pro-inflammatory agents produced by α-syn |
Zhang et al.86 | miR-150 | Downregulated | AKT3 | Inhibit the release of proinflammatory cytokines including TNF-α, IL-1β and IL-6 |
Feng et al.87. | miR-330 | Upregulated | SHIP1 | MG SHIP1 target protein negatively controls the activity of NF-κB |
Runxiao Lv146 | miR155-5p | Downregulated | SHIP1 | Suppress the activity of NF-κB |
He et al.88 | miR-7116-5p | Downregulated | TNF-α | Inhibition of the production of TNF-α and the activation of MG. |
Zhou et al.90. | miR-7 | Downregulated | NLRP3 | Inhibits the activation of NLRP3 inflammasomes in MG |
Sun et al.91. | miR-190 | Downregulated | NLRP3 | Inhibit the release of pro-inflammatory factors, including TNF-α, TGF-β1, iNOS, and IL-6 |
Wang et al.92. | miR-29c | Downregulated | NFAT5 | Overexpression suppresses pro-inflammatory cytokine release, along with NF-κB and TXNIP/NLRP3 inflammasome activation |
Li et al.93. | miR-30e | Downregulated | NLRP3 | Inhibition of NLRP3 mRNA and protein expression |
