Table 3 Six months after surgery, in the cross-over period (V4/5), there were no significant differences between OS and DS with regard to motor and non-motor symptoms during the chronic evaluation (i.e., after 3-week stimulation blocks of each condition)

From: Randomized crossover trial on motor and non-motor outcome of directional deep brain stimulation in Parkinson’s disease

 

Omnidirectional

Directional

Omnidirectional vs. Directional

Mean ± SD

Mean ± SD

p value

z value

n

MDS-UPDRS I

11.16 ± 8.49

11.00 ± 5.94

0.909

−0.114

17

MDS-UPDRS II

18.16 ± 9.32

19.06 ± 9.19

0.568

−0.571

18

MDS-UPDRS III

28.63 ± 12.91

32.42 ± 15.07

0.121

−1.550

19

MDS-UPDRS IV

8.17 ± 4.89

8.78 ± 4.45

0.925

−0.095

17

VDR

 Task accuracy

0.70 ± 0.29

0.69 ± 0.23

1.000

0.000

17

 Task reaction time

2.56 ± 0.51

2.54 ± 0.59

0.845

−0.196

18

 Oddball accuracy

0.96 ± 0.08

0.94 ± 0.11

0.271

−1.100

18

 Oddball reaction time

0.91 ± 0.32

0.85 ± 0.27

0.267

−1.111

18

SDR

 Task accuracy

0.25 ± 0.12

0.22 ± 0.09

0.355

−0.924

17

 Task reaction time

1.83 ± 0.64

1.71 ± 0.53

0.918

−0.103

16

 Oddball accuracy

0.64 ± 0.26

0.57 ± 0.26

0.265

−1.115

17

 Oddball reaction time

1.09 ± 0.35

1.01 ± 0.33

0.469

−0.724

16

FoG-AC

11.47 ± 13.02

12.80 ± 13.80

0.129

−1.517

15

CAPSIT

 Steps

39.11 ± 20.55

42.00 ± 22.02

0.072

−1.801

17

 Time (s)

27.44 ± 23.74

31.82 ± 34.04

0.142

−1.468

17

 Freezing episodes

1.56 ± 3.75

1.53 ± 3.63

0.131

−1.511

17

MoCA

26.53 ± 3.15

27.83 ± 1.92

0.080

−1.753

17

 Executive

3.89 ± 1.05

4.47 ± 0.84

0.071

−1.805

19

 Naming

2.84 ± 0.69

3.00 ± 0.00

0.317

−1.000

18

 Attention

5.58 ± 0.69

5.44 ± 0.86

0.206

−1.265

18

 Language

2.44 ± 0.62

2.32 ± 0.82

0.366

−0.905

18

 Abstraction

1.89 ± 0.32

2.00 ± 0.00

0.157

−1.414

18

 Delayed recall

3.95 ± 1.31

4.37 ± 0.83

0.323

−0.988

19

 Orientation

5.95 ± 0.23

6.00 ± 0.00

0.317

−1.000

19

BDI

13.56 ± 7.25

14.88 ± 6.91

0.448

−0.758

17

AS

16.11 ± 4.58

17.58 ± 4.49

0.646

−0.406

16

DBS-IS

25.94 ± 14.61

28.06 ± 12.52

0.674

−0.421

17

LARS

−22.47 ± 7.33

−20.61 ± 10.14

0.275

−1.091

18

PDQ-39

 Mobility

19.22 ± 10.73

21.13 ± 8.16

0.380

−0.877

15

 Activities of daily living

9.06 ± 5.68

9.72 ± 5.06

1.000

0.000

17

 Emotions

8.06 ± 4.56

9.00 ± 4.04

0.318

−0.999

17

 Stigma

3.50 ± 3.24

4.39 ± 2.43

0.304

−1.027

17

 Social support

1.94 ± 2.31

2.53 ± 2.27

0.094

−1.672

17

 Cognition

5.00 ± 3.27

6.38 ± 2.90

0.477

−0.711

15

 Communication

4.06 ± 3.42

4.53 ± 2.74

0.832

−0.212

16

 Bodily discomfort

5.11 ± 2.61

5.35 ± 2.34

0.640

−0.467

16