Fig. 2: Integrity of caudate dopamine terminals is related to the development of RT.

A Top: Patient groups were sorted by the baseline (Year 0) presence of tremor and included in four different groups depending on maintaining or switching their phenotype. Bottom: Age at inclusion for the different groups (F3,405 = 4.802 P = 0.0027; Post-hoc comparisons (Holm–Šídák’s multiple comparisons test: Tremor->Tremor vs. No-tremor->Tremor (63.50 ± 0.63 vs. 58.97 ± 1.64, P = 0.030), Tremor->Tremor vs. No-Tremor-> No-tremor (63.50 ± 0.63 vs. 59.79 ± 1.04, P = 0.0133)). B Left: CBR at baseline and during the 2-year follow-up for the different groups. Right, PBR at baseline and during the 2-year follow-up for the different groups.