Fig. 2: A map illustrates that Egypt is centrally located in a region with the highest prevalence of the p.Gly2019Ser pathogenic variant globally. | npj Parkinson's Disease

Fig. 2: A map illustrates that Egypt is centrally located in a region with the highest prevalence of the p.Gly2019Ser pathogenic variant globally.

From: The p.Gly2019Ser is a common LRRK2 pathogenic variant among Egyptians with familial and sporadic Parkinson’s disease

Fig. 2

The map’s arrows depict potential migration routes through which this pathogenic variant could have been introduced to Egypt. We speculate that the p.Gly2019Ser pathogenic variant might have been brought to Egypt via east-west migration during the movements of Islamic Arab and North African Berbers, known as the Maghrebi Effect (red arrow), or through maritime invasion and trades activities across the Mediterranean involving the Byzantines, Vandals, Romans, Greeks, and Phoenicians (orange, blue, yellow, gray, and green arrows), known as the “back to Africa” gene flow.

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