Table 2 Demographic and clinical characteristics of p.Gly2019Ser carriers vs non-carriers

From: The p.Gly2019Ser is a common LRRK2 pathogenic variant among Egyptians with familial and sporadic Parkinson’s disease

 

All cohort

Parameter

Non-G2019S carriers (n = 523)

G2019S carriers (n = 24)

P value*

P1 value*

Gender distribution, n (%)

Female

Male

183 (34.99)

340 (65.01)

7 (29.17)

17 (70.83)

0.664

—

Age at Study (y),mean ± SD (range)

60.69 ± 9.79 (31–94)

59.67 ± 8.32 (42–79)

0.523

—

Age at onset (y), mean ± SD (range)

53.82 ± 8.67 (21–83)

52 ± 8.07 (38–67)

0.377

—

Young onset PD ( < 40 y), n (%)

28 (5.35)

1 (4.17)

> 0.9999

—

Early onset PD (40–50 y), n (%)

147 (28.11)

8 (33.33)

0.644

—

Late onset PD ( > 50 y), n (%)

348 (66.54)

15 (62.50)

0.665

—

Age at Diagnosis (y), mean ± SD (range)

54.28 ± 8.77 (21–83)

52 ± 8.07 (38–67)

0.246

—

Family History n (%)

58 (11.09)

4 (16.67)

0.336

—

Duration of illness, mean ± SD (range)

6.88 ± 5.47 (0–33)

7.67 ± 5.90 (0–25)

0.393

—

MDS UPDRS mean ± SD (range)

118.83 ± 48.94 (7–223)

120.48 ± 59.61 (38–231)

0.151

0.099

  1. * P values for categorical variables were calculated using Fisher’s exact test and for continuous variables using the Mann–Whitney U test. P1 is P values following adjustment for sex, age, and duration of disease using Univariate Analysis of Variance (ANCOVA).
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