Table 2 Statistical analysis of inter-group T1 features

From: Multimodal neuroimaging-based prediction of Parkinson’s disease with mild cognitive impairment using machine learning technique

variable

HC group n = 32

PDNC group n = 69

PDMCI group n = 72

P value

lh inferiorparietal_Cth (mm)

2.37 ± 0.1

2.38 ± 0.1c

2.33 ± 0.1b

0.01

lh medialorbitofrontal_Cth (mm)

2.39 ± 0.1c

2.37 ± 0.2c

2.31 ± 0.2ab

0.03

lh middletemporal_Cth (mm)

2.66 ± 0.1

2.68 ± 0.1c

2.63 ± 0.1b

0.02

lh postcentral_Cth (mm)

2.06 ± 0.1c

2.06 ± 0.2c

2 ± 0.2ab

<0.01

lh superiortemporal_Cth (mm)

2.66 ± 0.1

2.65 ± 0.1c

2.58 ± 0.1b

<0.01

lh supramarginal_Cth (mm)

2.43 ± 0.1c

2.41 ± 0.1c

2.35 ± 0.1ab

0.02

lh MeanThickness (mm)

2.4 ± 0.1

2.4 ± 0.1c

2.36 ± 0.1b

0.04

rh parsorbitalis_Cth (mm)

2.53 ± 0.1c

2.5 ± 0.2c

2.43 ± 0.2ab

0.04

rh pericalcarine_Cth (mm)

1.59 ± 0.1b

1.66 ± 0.2ac

1.61 ± 0.1b

0.04

rh precentral_Cth (mm)

2.47 ± 0.2

2.5 ± 0.1c

2.44 ± 0.1b

0.03

lh Caudate_volume (mm3)

3244 ± 344

3240 ± 490c

3067 ± 498b

0.04

lh Hippocampus_volume (mm3)

3884 ± 368c

3877 ± 433c

3639 ± 443ab

<0.01

lh Amygdala_volume (mm3)

1640 ± 206

1695 ± 214c

1579 ± 265b

<0.01

lh Accumbens_volume (mm3)

521 ± 101

552 ± 111c

498 ± 102b

<0.01

rh Hippocampus_volume (mm3)

4048 ± 352c

4065 ± 473c

3826 ± 436ab

<0.01

rh Accumbens_volume (mm3)

1828 ± 176

1900 ± 246c

1759 ± 288b

<0.01

rh Accumbens_volume (mm3)

493 ± 82

513 ± 876c

463 ± 81b

<0.01

  1. The data were presented as mean ± standard deviation. When comparing between the three groups, a p-value less than 0.05 indicated statistical significance compared to the HC group (denoted as “a”), PDNC group (“b”), or PDMCI group (“c”).
  2. Cth cortical thickness, HC healthy control, lh left hemisphere, PDMCI Parkinson’s disease with mild cognitive impairment, PDNC Parkinson’s disease normal cognitive, rh rihgt hemisphere.