Table 4 Comparison of the performance of classifiers using different combinations of indicators

Classifiers	Features					ACC	AUC	Sensitivity	Specificity
Classifiers	clinical	T1	Rs-fMRI	NfL	GFAP	ACC	AUC	Sensitivity	Specificity
1	√	×	√	√	×	0.762	0.840	0.745	0.783
2	√	×	√	×	√	0.759	0.834	0.783	0.736
3	√	×	×	×	√	0.758	0.832	0.781	0.739
4	√	√	√	×	√	0.756	0.830	0.706	0.813
5	√	√	√	√	×	0.749	0.830	0.705	0.798
6	√	×	√	√	√	0.748	0.830	0.780	0.719
7	√	√	×	√	×	0.749	0.828	0.769	0.809
8	√	√	×	×	√	0.746	0.825	0.681	0.784
9	√	√	√	√	√	0.741	0.824	0.697	0.775
10	√	×	×	√	×	0.753	0.822	0.735	0.771
11	√	√	×	√	√	0.739	0.821	0.678	0.784
12	√	√	√	×	×	0.755	0.819	0.667	0.842
13	√	×	×	√	√	0.746	0.818	0.765	0.707
14	√	√	×	×	×	0.716	0.790	0.648	0.794
15	×	√	×	√	√	0.716	0.790	0.648	0.794
16	√	×	×	×	×	0.651	0.790	0.651	0.831
17	√	×	√	×	×	0.748	0.773	0.647	0.833
18	×	√	√	×	√	0.665	0.739	0.610	0.736
19	×	×	√	√	√	0.644	0.739	0.691	0.614
20	×	√	×	×	√	0.671	0.737	0.605	0.750
21	×	√	√	√	√	0.655	0.735	0.590	0.735
22	×	√	×	√	×	0.700	0.731	0.589	0.824
23	×	√	√	√	×	0.668	0.729	0.606	0.743
24	×	×	√	√	×	0.657	0.724	0.669	0.656
25	×	×	√	×	√	0.650	0.710	0.691	0.623
26	×	√	√	×	×	0.613	0.670	0.621	0.623
27	×	×	√	×	×	0.641	0.651	0.512	0.784
28	×	√	×	×	×	0.513	0.499	0.621	0.449
29	×	×	×	√	√	0.457	0.494	0.545	0.422

ACC accuracy, AUC area under curve, Rs-fMRI resting-state functional magnetic resonance imaging, NfL neurofilament light chain, GFAP glial fibrillary acidic protein.

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