Fig. 2: Density of CD11b+ cells in the SNpc of wild-type, mGlu2−/− and mGlu3−/− mice challenged with MPTP.
From: Preclinical and clinical study on type 3 metabotropic glutamate receptors in Parkinson’s disease
Representative images of CD11b+ cells in the SNpc of the three genotypes are shown in (A). Cell density is shown in (B) where values are means + S.E.M. Number of mice per group: wild-type saline and MPTP = 5; mGlu2−/− saline = 13; mGlu2−/− MPTP = 4; mGlu3−/− saline = 12; mGlu3−/− MPTP = 11. Significant difference vs. the respective saline (*) or vs. wild-type mice treated with MPTP (#). Two-way ANOVA + Fisher LSD; genotype, F2,44 = 6.918; p = 0.002; treatment, F1,44 = 15.334; p < 0.001; interaction, F2,44 = 6.229; p = 0.004. Wild-type, MPTP vs. saline, p = 0.102; mGlu2−/−, MPTP vs. saline, p = 0.833; mGlu3−/−, MPTP vs. saline, p < 0.001; mGlu2−/− MPTP vs. wild-type MPTP, p = 0.202; mGlu3−/− MPTP vs. wild-type MPTP, p = 0.005; mGlu2−/− MPTP vs. mGlu3−/− MPTP, p < 0.001.
