Fig. 7: Longitudinal patient data validation for potential PD drug candidates. | npj Parkinson's Disease

Fig. 7: Longitudinal patient data validation for potential PD drug candidates.

From: A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson’s disease

Fig. 7

A Basic characteristics of the INSIGHT patient database. B Trial emulation design for each drug with consideration of two kinds of PD outcomes: fall and dementia. C Perform propensity score matching (PSM) to control confounding factors and build balanced trials. D Network-predicted mechanism-of-actions (MOA) for Simvastatin, along with the forest plot of the hazard ratio (HR).

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