Fig. 2: MCS preserves LFP α augmentation in STN but not in MC. | npj Parkinson's Disease

Fig. 2: MCS preserves LFP α augmentation in STN but not in MC.

From: Motor cortex stimulation ameliorates parkinsonian locomotor deficits: effectual and mechanistic differences from subthalamic modulation

Fig. 2

a Time-frequency power plot in MC and STN (upper two panels), aligned with moving velocity (lower panel), before, during, and after MCS (lower two panels). Note the increase in moving velocity and α power in STN but not MC. b Sample recordings of time-varying relative α band power and moving velocity reveals a positive correlation between α power in either MC or STN and moving velocity with sham stimulation. The correlation is present only in STN but not MC during MCS. c Electrophysiological data in specific locomotor behavior states are deliberately selected and analyzed (created in BioRender). d Power spectral density plot (left) and band power analysis in α band frequency (7–10 Hz) (right). The STN α augmentation (increase in α power) from quiescence to active moving (see Methods) and the augmented MC-STN α coherence upon active moving are preserved with MCS, which markedly attenuates the α augmentation in MC (n = 39 from 13 rats and 34 from 14 rats for sham and MCS, respectively). e–g Similar experiments and analyses to that in part (a–d), but in normal rats (n = 43 from 14 rats and 53 from 19 rats, sham and MCS, respectively). Once again, the α augmentation from quiescence to active moving is preserved in STN but abolished in MC. The augmented MC-STN α coherence upon active moving is also preserved. ***p < 0.001, N.S. nonsignificant, Mann-Whitney U tests.

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