Fig. 5: Hyperpolarizing MCS increases MC MU spatiotemporal changes in parkinsonian rats.

a Sample raster plots of multi-unit spikes from 7 MC leads and concomitant dissimilarity score (S) of the 7 leads, from a segment at quiescence (upper) and the other one during active moving (lower) at baseline (left) and during MCS (right) in a PD rat. b and c The average power-frequency spectra of the whole temporal profile of S (S(t)) in all segments in part A show an increase in MC spatiotemporal changes from quiescence to active moving with MCS (if compared to that with sham) (n = 27 and 26, sham and MCS, respectively). d The total powers (1-100 Hz) of the spectral analyses in parts B and C show a significant increase of spatiotemporal changes from quiescence to active moving with MCS but not at baseline in PD rats. e Sample raster plots of multi-unit spikes from 7 MC leads and concomitant dissimilarity score (S) of the 7 leads, from a segment at rest (upper) and the other one during movement (lower) at baseline (left) and during MCS (right) in a normal rat. f and g The average power-frequency spectra of the whole temporal profile of S (S(t)) in part E show a decrease in MC spatiotemporal change from quiescence to active moving with MCS (if compared to that with sham) (n = 16 and 17, sham and MCS, respectively). h The total powers (1-100 Hz) of the spectral analyses from segments in parts f and g show a significant increase of spatiotemporal changes from quiescence to active moving at baseline but not during MCS in normal rats. **p < 0.01, N.S., nonsignificant, Mann-Whitney U tests.