Table 3 Shared risk loci between biomarkers and Parkinson’s disease

From: Early detection of Parkinson’s disease through multiplex blood and urine biomarkers prior to clinical diagnosis

SNP

Genomic position

Closest gene

FDR-value

P-value in PD GWAS

P-value in Biomarker GWAS

Immature reticulocyte fraction

 rs1870293

16:30970941

SETD1A

3.09 × 10-6

1.13 × 10-9

8.20 × 10-9

 rs17573509

17:44081224

MAPT

2.67 × 10-6

1.58 × 10-12

6.87 × 10-9

IGF-1

 rs7760841

6:32574868

HLA-DRB1; HLA-DQA1

2.66 × 10-4

1.41 × 10-6

6.31 × 10-18

C-reactive protein

 rs7760841

6:32574868

HLA-DRB1; HLA-DQA1

1.27 × 10-4

1.41 × 10-6

5.44 × 10-8

  1. SNP, single nucleotide polymorphism; FDR, false discovery rate. The genomic position was based on GRCh37.
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