Table 1 Demographic and clinical characteristics of participants

From: Transcutaneous auricular vagus nerve stimulation improves cortical functional topological properties and intracortical facilitation in patients with Parkinson’s disease

Variables

PD

HCs

p value

RS

SS

n

15

15

20

 

Age (y)

64.13 ± 5.66

62.67 ± 7.76

63.10 ± 7.77

0.848a

Sex (M/F)

6/9

10/5

13/7

0.239b

Education (y)

12.07 ± 3.28

13.20 ± 2.40

11.65 ± 3.39

0.406c

MoCA

26.33 ± 1.59

26.47 ± 0.99

27.15 ± 1.27

0.142a

HAMD-24

3.47 ± 2.20

3.80 ± 1.61

2.65 ± 1.98

0.272c

HAMA

3.53 ± 1.81

3.67 ± 1.88

2.75 ± 2.07

0.319a

Age at onset

59.80 ± 7.37

58.53 ± 8.04

NA

0.656d

Disease duration (y)

4.33 ± 2.87

4.13 ± 2.70

NA

0.845d

Initial side of onset of motor symptoms (R/L)

7/8

8/7

NA

0.715b

UPDRS-III

15.80 ± 5.98

15.73 ± 5.13

NA

0.835e

H&Y stage (1/1.5/2)

7/4/4

4/7/4

NA

0.433f

LEDD, mg/d

465.63 ± 246.67

449.03 ± 202.29

NA

0.842d

ΔUPDRS-III

−2.73 ± 2.84

0.13 ± 3.00

NA

0.012d, *

  1. Values are presents as the mean ± standard deviation. PD Parkinson’s disease, HCs healthy controls, RS real taVNS stimulation group, SS sham stimulation group, M male, F female, y year, MoCA Montreal Cognitive Assessment, HAMD-24 Hamilton Depression Scale-24, HAMA Hamilton Anxiety Scale, R right, L left, UPDRS Unified Parkinson’s disease rating scale, H-Y stage Hoehn and yahr clinical rating scale, LEDD levodopa equivalent daily dose, NA not applicable.
  2. aOne-way ANOVA. bChi-square test. cKruskal–Wallis. dtwo-sample t test. eMann–Whitney U. fFisher Exact test.
  3. p < 0.05 was considered statistically significant. *p < 0.05.