Fig. 6: SVHRSP decreases intestinal barrier permeability in the colon and reduces the contents of LPS and HMGB1 in the serum of rotenone-induced PD mice. | npj Parkinson's Disease

Fig. 6: SVHRSP decreases intestinal barrier permeability in the colon and reduces the contents of LPS and HMGB1 in the serum of rotenone-induced PD mice.

From: SVHRSP protects against rotenone-induced neurodegeneration in mice by inhibiting TLR4/NF-κB-mediated neuroinflammation via gut microbiota

Fig. 6

a Representative western blot bands of ZO-1, Claudin-1, and Occludin in the colon. b Quantitative assessment of ZO-1, Claudin-1, and Occludin expression. c Representative images of ZO-1 immunostaining in the colon. Scale bars represent 250 µm. d Statistical result of ZO-1 density. e Levels of LPS and HMGB1 in mouse serum. n = 4. *p < 0.05, **p < 0.01, ****p < 0.0001.

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