Fig. 8: SVHRSP inhibits microglial activation and TLR4/NF-κB pathway activation via gut microbiota in rotenone-induced PD mice. | npj Parkinson's Disease

Fig. 8: SVHRSP inhibits microglial activation and TLR4/NF-κB pathway activation via gut microbiota in rotenone-induced PD mice.

From: SVHRSP protects against rotenone-induced neurodegeneration in mice by inhibiting TLR4/NF-κB-mediated neuroinflammation via gut microbiota

Fig. 8

Levels of LPS (a) and HGM1 (b) in serum measured by ELISA (n = 4). Representative images (c) and statistical analysis (d) of Iba-1 immunostaining in the substantia nigra (SN) of mice (n = 5). Scale bars represent 100 µm. Representative western blots (e) and densitometry analysis (f) of CD11b, TLR4, NF-κB, and P-NF-κB in the midbrain tissues of mice (n = 4). The mRNA expression levels of TNF-α (g) and iNOS (h) in the midbrain of mice (n = 4). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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