Fig. 1: Reference regions and regions of interest. | npj Parkinson's Disease

Fig. 1: Reference regions and regions of interest.

From: High-resolution mapping of substantia nigra in Parkinson’s disease using 7 tesla magnetic resonance imaging

Fig. 1

a A midbrain search-space (green) and lateralized cylindrical reference regions (blue and red) were manually defined on the MNI-template and used to calculate lateralized MT CNR maps of the midbrain. b For the ROI analysis in patients, the ROIs were defined manually on MT-weighted, high-resolution QSM and low-resolution R2* templates constructed by averaging data from all healthy controls. For each modality an ROI was defined for the right (blue) and left (red) SN and N1 (based on dorsal nigral hyperintensity, low quantitative susceptibility and low R2* for the MTw, QSM and R2* modalities respectively). Mean MT CNR, R2* and QSM values were extracted from each lateralized ROI for the assessment of correlations with contralateral motor severity and motor asymmetry.

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