Fig. 2: Threshold free cluster enhancement (TFCE) of the midbrain. | npj Parkinson's Disease

Fig. 2: Threshold free cluster enhancement (TFCE) of the midbrain.

From: High-resolution mapping of substantia nigra in Parkinson’s disease using 7 tesla magnetic resonance imaging

Fig. 2

TFCE analyses in a midbrain search-space (ROI) a of the between group difference revealed a decrease in MT-weighted contrast to noise ratio (MT CNR) in patients with PD compared to healthy controls in areas corresponding to the bilateral nigrosomes N1 and N4 and right N2, b Patients had increased QSM values in areas corresponding to bilateral nigrosomes N1 and N2, c No significant voxel-wise difference was found for R2*, d Statistical maps in b and c are thresholded at family-wise error corrected p < 0.05. In d, the statistical map is thresholded at t > 2 for visualization purposes, none of the differences are significant after correction for multiple comparisons.

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