Table 4 Changes in OFF/ON time, dyskinesia, FOG-Q, SMA, and fluency measured with the Parkinson Holter throughout the study

From: Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial

Variable

Visit Group, n = 50

Diary Group, n = 47

Sensor Group, n = 44

Regression analysis

Comparison

Estimate

CI

p-value

Percentage OFF time, Mean (SD)

Baseline

15.2 (9.55)

17.4 (9.09)

19.0 (9.20)

DG vs. VGa

−1.36

−4.59 to 1.87

0.407

Final

15.6 (9.26)

15.3 (9.62)

18.7 (9.99)

SG vs. VGa

0.92

−2.46 to 4.30

0.591

p-value (Baseline vs. Final)

0.9538

0.4968

0.763

 

Percentage ON time, Mean (SD)

Baseline

43.8 (17.4)

36.9 (15.6)

39.3 (16.5)

DG vs. VGb

4.83

−0.66 to 10.32

0.084

Final

43.3 (17.8)

42.9 (17.3)

40.2 (15.0)

SG vs. VGb

2.05

−3.60 to 7.69

0.474

p-value (Baseline vs. Final)

0.9697

0.0852

0.9359

 

Dyskinesia (%), Mean (SD)

Baseline

17.4 (17.5)

15.3 (14.3)

18.1 (14.9)

DG vs. VGc

4.45

−0.75 to 9.65

0.092

Final

17.6 (16.1)

19.7 (16.2)

19.5 (16.4)

SG vs. VGc

4.74

−0.63 to 10.11

0.083

p-value (Baseline vs. Final)

0.9001

0.2559

0.5873

 

FOG-Q (%), Mean (SD)

Baseline

0.38 (0.69)

0.21 (0.28)

0.34 (0.61)

DG vs. VGd

0.06

−0.12 to 0.23

0.535

Final

0.37 (0.89)

0.25 (0.36)

0.35 (0.68)

SG vs. VGd

0.01

−0.17 to 0.19

0.905

p-value (Baseline vs. Final)

0.9361

0.6591

0.9654

 

SMA (m/s2), Mean (SD)

Baseline

0.43 (0.15)

0.35 (0.11)

0.38 (0.10)

DG vs. VGe

0.01

−0.02 to 0.05

0.368

Final

0.41 (0.14)

0.37 (0.12)

0.39 (0.12)

SG vs. VGe

−0.00

−0.04 to 0.03

0.818

p-value (Baseline vs. Final)

0.5646

0.313

0.9593

 

Stride fluidity (m/s2), Mean (SD)

Baseline

8.65 (1.44)

7.30 (1.47)

7.69 (1.29)

DG vs. VGf

0.22

−0.11 to 0.55

0.183

Final

8.56 (1.59)

7.63 (1.58)

7.78 (1.40)

SG vs. VGf

−0.16

−0.48 to 0.17

0.340

p-value (Baseline vs. Final)

0.7579

0.2955

0.7513

 
  1. CI Confidence interval, DG Diary Group, FOG-Q Freezing of Gait Questionnaire, SG Sensor Group, SMA Signal magnitude area, VG Visit Group.
  2. aObservations = 119, R2/R2 adjusted=0.497/0.470, AIC = 815.654.
  3. bObservations = 119, R2/R2 adjusted=0.506/0.480, AIC = 940.408.
  4. cObservations = 119, R2/R2 adjusted=0.512/0.486, AIC = 929.521.
  5. dObservations = 119, R2/R2 adjusted=0.714/0.698, AIC = 123.830.
  6. eObservations = 119, R2/R2 adjusted=0.744/0.730, AIC = -291.272.
  7. fObservations = 119, R2/R2 adjusted=0.811/0.801, AIC = 260.373.
  8. Model adjusted by the equivalent dopaminergic dose, UPRS-II, UPDRS-III, and the corresponding variable at baseline.
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