Fig. 4: Performanceof plasma biomarkers in differentiating and identifying DLB.
From: Genetic risk and plasma biomarkers of dementia with Lewy bodies in a Chinese population
A−D Comparisons of plasma biomarkers levels in healthy controls, mild DLB, and moderate-severe DLB. ANCOVA analysis was conducted for multiple comparisons with age and gender as covariates. The Bonferroni corrections were applied to p_values of multiple comparisons. E ROC curves of each plasma biomarker and the combination with PRS for discriminating DLB from controls; F ROC curves of each plasma biomarker and the combination with PRS for discriminating mild DLB from controls. DLB dementia with Lewy bodies, Mod-Sev DLB moderate-severe DLB, HC healthy controls, P-tau phosphorylated tau, NfL neurofilament light chain, GFAP glial fibrillary acidic protein, αSyn α-synuclein, ANCOVA analysis of covariance, ROC receiver-operating characteristic, AUC area under the curve, PRS polygenic risk score. ***p < 0.001; ****p < 0.0001.
