Fig. 1: Research design and analytical procedure. | npj Parkinson's Disease

Fig. 1: Research design and analytical procedure.

From: Mapping striatal functional gradients and associated gene expression in Parkinson’s disease with continuous cognitive impairment

Fig. 1

Top panel: Participants. A total of 115 PD patients and 36 HC were included, categorized into PD-NC, PD-MCI, and PDD groups. Middle panel: Gradient construction. Functional connectivity gradients of the striatal cortex were computed using voxel-wise striatal cortex-to-cerebrum rsFC profiles and diffusion embedding. Bottom panel: Further analyzes. We investigated the associations of striatal functional connectivity gradients with canonical functional networks, the neurotransmitter atlas, and the Allen Human Brain Atlas. BOLD blood-oxygen-level-dependent, rsFC resting-state functional connectivity, HC healthy controls, NC normal cognitive, MCI mild cognitive impairment, PDD Parkinson’s disease dementia.

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