Fig. 2: The distribution of the first three striatal functional connectivity gradients.

The template for Gradient 1, derived from the Human Brainnetome Atlas, reflects the anatomical subdivisions of the striatum. Based on previous studies1, the templates for Gradient 2 and Gradient 3 correspond to striatal gradients associated with dopaminergic projections and cortico-striatal connectivity, respectively. HC healthy controls, NC normal cognitive, MCI mild cognitive impairment, PDD Parkinson’s disease dementia.