Fig. 5: The potential molecular mechanisms of group-related striatalal gradient alterations. | npj Parkinson's Disease

Fig. 5: The potential molecular mechanisms of group-related striatalal gradient alterations.

From: Mapping striatal functional gradients and associated gene expression in Parkinson’s disease with continuous cognitive impairment

Fig. 5

The top panel shows the explained ratios (left vertical axis) and correlation coefficients (right vertical axis) for the first 15 components obtained from PLS regression analysis. A The top 20 enriched terms that remained significant after FDR correction for positive weight (left) and negative weight (right) gene sets associated with striatum gradient differences between PD-NC and PDD patients. B The top 20 enriched terms that remained significant after FDR correction for positive weight (left) and negative weight (right) gene sets associated with striatum gradient differences between PD-MCI and PDD patients. C The top 20 enriched terms that remained significant after FDR correction for positive weight (left) and negative weight (right) gene sets associated with striatal striatum differences between PDD patients and HC. In (A–C) the length of the bar denotes the number of input genes falling under that term, and its color denotes the enrichment significance.

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