Table 1 Demographic and clinical characteristics

Age(years)

61.00 (9.50)

62.00 (13.00)

62.00 (6.00)

63.00 (5.75)

0.591

1.000

0.228

0.948

0.091

0.388

Gender(male/female)

20/25

28/22

17/14

18/22

0.261

0.919

0.373

0.300

0.959

0.411

Education(years)

12.00 (5.50)

9.50 (3.25)

9.00 (4.00)

12.00 (5.50)

1.000

0.601

0.324

0.069

0.191

0.004^a

Duration(years)

5.00 (5.50)

3.00 (4.00)

5.00 (4.00)

–

0.104

0.132

0.472

–

–

–

HY

2.00 (0.75)

2.00 (0.63)

2.00 (1.50)

–

0.230

1.000

0.306

–

–

–

MDS-UPDRSIII

16.00 (17.50)

25.75 (21.5)

35.00 (11.00)

–

0.804

0.132

0.387

–

–

–

MMSE

29.00 (1.25)

29.00 (2.25)

24.00 (2.00)

−0.62 (0.46)

−1.78 (0.87)

−1.80 (0.50)

−3.01 (0.35)

−1.36 (0.47)

19.00 (5.00)

29.00 (2.00)

0.661

3.53e-11^a

3.43e-14^a

0.145

1.000

1.80e-15^a

MoCa

27.00 (2.00)

15.00 (5.00)

27.00 (2.00)

3.49e-10^a

4.24e-04^a

1.63e-20^a

1.45e-11^a

1.000

7.78e-22^a

Attention

−0.40 (0.22)

−1.43 (0.61)

−0.08 (0.89)

0.014^a

5.18e-05^a

1.46e-9^a

8.98e-04^a

0.949

9.69e-11^a

Execution

−1.37 (0.20)

−2.86 (0.88)

−0.07 (0.34)

0.004^a

1.55e-04^a

7.84e-10^a

3.94e-08^a

0.030^a

2.59e-16^a

Language

−1.35 (0.25)

−2.34 (0.56)

−0.04 (0.90)

4.84e-04^a

8.42e-05^a

9.97e-12^a

2.31e-07^a

0.200

1.10e-15^a

Memory

−2.41 (0.23)

−3.86 (0.54)

0.03 (1.06)

1.42e-04^a

6.28e-05^a

9.86e-13^a

1.67e-08^a

0.134

2.11e-17^a

Visuospatial

−1.03 (0.35)

−2.08 (0.36)

0.06 (0.73)

0.031^a

8.27e-05^a

1.12e-08^a

1.19e-07^a

0.115

4.36e-16^a

LEDD

337.50 (412.50)

300.00 (362.50)

450.00 (380.00)

–

1.000

0.839

1.000

–

–

–