Table 3 Voxel-level group-related alteration in striatum gradient

From: Mapping striatal functional gradients and associated gene expression in Parkinson’s disease with continuous cognitive impairment

Brain regions

Cluster size

Peak coordinates

T value

P value

 

(voxels)

X

Y

Z

  

Gradient2

PD-MCIvsPDD

 dorsolateral Putamen.R

15

27

12

−3

5.572

0.019*

 Nucleus accumbens.R

16

9

9

−6

−4.715

0.003*

Without LEDD

PD-MCIvsPDD

 Nucleus accumbens.R

14

6

15

−6

−4.390

0.036*

PD-MCIvsPD-NC

      

 dorsolateral Putamen.R

13

30

−9

−3

4.720

0.014*

Gradient3

PD-NCvsPDD

 Nucleus accumbens.L

36

−12

15

−9

7.424

<0.001*

 Nucleus accumbens.R

42

12

9

−9

7.564

<0.001*

 dorsal Caudate.L

12

−15

-6

21

−6.048

0.003*

 dorsal Caudate.R

29

18

18

9

−5.656

<0.001*

PD-MCIvsPDD

 Nucleus accumbens.L

38

−12

15

−9

6.839

<0.001*

 Nucleus accumbens.R

33

12

9

-9

4.922

<0.001*

 ventral Caudate.R

50

12

15

3

−6.651

<0.001*

 dorsal Caudate.L

15

−12

0

12

−4.489

0.001*

PDDvsHC

 ventral Caudate.R

20

9

21

0

−4.745

0.048*

  1. The negative t value represents lower gradient scores and the positive t value represents higher gradient scores. P value: FDR corrected.
  2. MNI Montreal Neurological Institute; x, y, z are the coordinates of primary peak locations in the MNI space, HC healthy controls, NC Normal cognitive, MCI mild cognitive impairment, PDD Parkinson’s disease dementia, L left, R right, * Indicates statistical significance.
Back to article page