Fig. 1: Striatal delta activity and cortico-striatal coherence increase at rest in 6-OHDA mice. | npj Parkinson's Disease

Fig. 1: Striatal delta activity and cortico-striatal coherence increase at rest in 6-OHDA mice.

From: Parkinsonism disrupts cortical function by dysregulating oscillatory, network and synaptic activity of parvalbumin positive interneurons

Fig. 1

A Experimental protocol: (orange, n = 13) 6-OHDA (blue, n = 8 controls, CNT). Striatal and cortical LFPs simultaneously recorded weekly, during rest and motor task. Recording grouped into: early (week = 1); intermediate (weeks 2–3); late (week = 4). B Average power spectral density (PSD) of striatal LFPs in control and 6-OHDA mice across stages. Zoomed inset shows low-frequencies. C Delta power in striatal LFPs across weeks in CNT and 6-OHDA. D Striatal-cortical spectral coherence in CNT and 6- across stages. Zoomed inset: low-frequencies part of the PSD. E Delta-range coherence in CNT and 6-OHDA across stages. F Maximal cross-correlation across recording stages of the dynamics of delta power in control and 6-OHDA. G Optimal time lag for cross-correlation across recording stages of the dynamics of delta power in CNT and 6-OHDA mice. H Windows of analysis during the task in relation to movement onset. Black line: representative force trace throughout the task; the onset of the movement is highlighted. The orange window = baseline period, without movement detection; pink = pre-onset (movement preparation) and green = post-onset (movement). Average modulation of striatal (I) and cortical (J) LFPs time-frequency scalogram centered around movement onsets (vertical dashed white line) normalized by a baseline ([−1500,−750] ms before movement onsets) across stages in CNT (n = 6) and 6-OHDA (n = 7). K, L Modulation of delta and epsilon power in striatal LFPs around movement onsets (0–250 ms) across recording stages in CNT and 6-OHDA. M Variation of mean force exerted detected from the robotic M-platform in CNT and 6-OHDA. N, O Cortical delta and epsilon power modulation in CNT and 6-OHDA mice. P Area under the force curve detected from the robotic M-platform in CNT and 6-OHDA. Data are expressed as mean ± Standard Error of Mean. *p ≤ 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. CNT (blue), 6-OHDA (orange). See also Supplementary Figs. 1 and 2 and Supplementary Table 1.

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