Fig. 4: Differential expression analysis of all samples by genetic cohort. | npj Parkinson's Disease

Fig. 4: Differential expression analysis of all samples by genetic cohort.

From: Decreased SNCA expression in whole-blood RNA analysis of Parkinson’s disease adjusting for neutrophils

Fig. 4

PD causal variants are colored purple, and mitochondrial genes are colored orange. Differentially expressed PD causal variants and mitochondrial genes are additionally labeled by gene name. a Idiopathic case samples with no SNCA/LRRK2/GBA1 mutations were compared to control samples with no PD-related mutations (i.e., HC). HC samples were compared to case samples with GBA1+ (b), LRRK2+ (c), and SNCA+ (d) mutations. e LRRK2+ case samples were compared to LRRK2− case samples. f GBA1+ case samples were compared to GBA1 case samples. g log(CPM) SNCA expression in HC, IPD, SNCA+ case, GBA1+ case, and LRRK2+ case samples corrected by predicted neutrophil percentage, stratified by genetic cohort. Adjusted p values are labeled according to the adjusted p value of SNCA differential expression from respective DE analyses. The dotted red line represents the median SNCA expression in HC samples. *, **, *** indicate p values less than 0.05, 0.01. and 0.001, while N.S. indicates no significance.

Back to article page