Table 1 Demographic information and genetic status of PPMI and PDBP participants and samples
Control | Case | Other | Total | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age | HC | SNCA+ | LRRK2+ | GBA1+ | Multiple | Unknown | IPD | SNCA+ | LRRK2+ | GBA1+ | Multiple | Unknown | None | SNCA+ | LRRK2+ | GBA1+ | Multiple | Unknown | |||
Samples with RNA-Seq Data | w/CBC data | 1254 | |||||||||||||||||||
<55 | 39 | – | – | 3 | – | – | 63 | – | 5 | 4 | – | – | – | – | – | – | – | – | |||
Female | 55–65 | 56 | – | – | 3 | – | – | 97 | – | 5 | 20 | – | 2 | – | – | – | – | – | – | ||
>65 | 40 | – | – | 5 | – | – | 106 | – | – | 5 | – | 2 | – | – | – | – | – | – | |||
<55 | 50 | – | – | – | – | – | 123 | – | – | 13 | – | 5 | – | – | – | – | – | – | |||
Male | 55–65 | 86 | – | – | 8 | – | 5 | 171 | – | 2 | 26 | – | – | – | – | – | – | – | – | ||
>65 | 86 | – | – | – | – | – | 199 | – | 6 | 15 | – | 4 | – | – | – | – | – | – | |||
w/out CBC data | 5643 | ||||||||||||||||||||
<55 | 129 | 9 | 55 | 42 | 6 | 55 | 154 | 17 | 47 | 18 | – | 6 | 8 | – | 1 | 3 | – | 2 | |||
Female | 55–65 | 189 | 1 | 121 | 53 | 16 | 26 | 312 | 4 | 80 | 66 | 7 | 25 | 15 | – | – | 1 | – | 1 | ||
>65 | 238 | – | 27 | 42 | 2 | 25 | 391 | 5 | 127 | 52 | 11 | 34 | 74 | – | 16 | 14 | – | 8 | |||
<55 | 119 | 3 | 41 | 17 | 2 | 42 | 264 | 18 | 41 | 23 | – | 23 | 1 | – | 2 | 5 | – | 3 | |||
Male | 55–65 | 188 | – | 69 | 28 | – | 22 | 475 | – | 53 | 65 | 6 | 24 | 72 | – | 3 | 1 | – | 1 | ||
>65 | 261 | – | 44 | 51 | 5 | 16 | 723 | – | 86 | 82 | 2 | 51 | 153 | – | 3 | 10 | 1 | 9 | |||
Total samples | 1481 | 13 | 357 | 252 | 31 | 191 | 3078 | 44 | 452 | 389 | 26 | 176 | 323 | 0 | 25 | 34 | 1 | 24 | 6897 | ||
Participants with RNA-seq data | Participants with paired CBC data for all timepoints with RNA-seq data | 22 | |||||||||||||||||||
<55 | 1 | – | – | – | – | – | 1 | – | – | – | – | – | – | – | – | – | – | – | |||
Female | 55–65 | – | – | – | – | – | – | 2 | – | – | 1 | – | – | – | – | – | – | – | – | ||
>65 | – | – | – | – | – | – | 1 | – | – | – | – | – | – | – | – | – | – | – | |||
<55 | – | – | – | – | – | – | 4 | – | – | 1 | – | – | – | – | – | – | – | – | |||
Male | 55–65 | 2 | – | – | – | – | – | 5 | – | – | 2 | – | – | – | – | – | – | – | – | ||
>65 | – | – | – | – | – | – | 2 | – | – | – | – | – | – | – | – | – | – | – | |||
Participants without any CBC data paired to RNA-seq data | 2176 | ||||||||||||||||||||
<55 | 52 | 5 | 37 | 36 | 3 | 31 | 42 | 6 | 15 | 7 | – | 5 | 6 | – | 1 | 3 | – | 2 | |||
Female | 55–65 | 81 | 1 | 51 | 30 | 10 | 13 | 86 | 1 | 31 | 25 | 3 | 10 | 10 | – | – | 1 | – | 1 | ||
>65 | 90 | – | 15 | 22 | 2 | 13 | 116 | 2 | 61 | 24 | 4 | 21 | 40 | – | 6 | 8 | – | 5 | |||
<55 | 35 | 1 | 28 | 17 | 1 | 25 | 70 | 8 | 17 | 10 | – | 8 | 1 | – | 1 | 4 | – | 2 | |||
Male | 55–65 | 55 | 0 | 36 | 16 | – | 8 | 134 | – | 24 | 25 | 3 | 13 | 35 | – | 2 | 1 | – | 1 | ||
>65 | 84 | 0 | 22 | 21 | 3 | 9 | 231 | – | 44 | 36 | 2 | 33 | 61 | – | 2 | 4 | 1 | 8 | |||
"Participants with RNA-seq data paired with CBC data for some, but not all RNA-seq data | 578 | ||||||||||||||||||||
<55 | 17 | – | – | 1 | – | – | 34 | – | 2 | 2 | – | – | – | – | – | – | – | – | |||
Female | 55–65 | 23 | – | – | 1 | – | – | 45 | – | 2 | 9 | – | 1 | – | – | – | – | – | – | ||
>65 | 16 | – | – | 2 | – | – | 47 | – | – | 2 | – | 1 | – | – | – | – | – | – | |||
<55 | 24 | – | – | – | – | – | 56 | – | – | 4 | – | 2 | – | – | – | – | – | – | |||
Male | 55–65 | 40 | – | – | 4 | – | 2 | 83 | – | 1 | 10 | – | – | – | – | – | – | – | – | ||
>65 | 40 | – | – | – | – | – | 95 | – | 2 | 8 | – | 2 | – | – | – | – | – | – | |||
Total participants | 560 | 7 | 189 | 150 | 19 | 101 | 1054 | 17 | 199 | 166 | 12 | 96 | 153 | 0 | 12 | 21 | 1 | 19 | 2776 | ||
